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Dose of sildenafil in pulmonary hypertension was similar to the single-dose effect in placebo-treated women (Figure 1). post hoc analysis, however, the mean increase in plasma sildenafil concentration of the postmenopausal women receiving a single oral dose of sildenafil in the early postmenopausal phase was significantly higher than that of the nonsarcastic placebo group [52]. PPT PowerPoint slide PowerPoint slide PNG larger image larger image TIFF original Download: Figure 1. Effect of single oral dose sildenafil (10 g) in the early postmenopausal phase on blood pressure response. Mean difference in systolic blood pressure between sildenafil and placebo, as measured by a repeated-measures analysis of variance (ANOVA). The data, expressed as difference in mean values with the error margin, are statistically significant except for the two subjects with severe hypertension (P<.05) (n = 25 in each group). *Significant increase means that the postmenopausal women receiving sildenafil had higher peak blood pressure than the nonsarcastic women. **Significant difference (p<.05) indicates that the postmenopausal women receiving sildenafil had a higher increase in systolic blood pressure than the nonsarcastic placebo group. https://doi.org/10.1371/journal.pone.0057777.g001 Discussion In this study, we tested sildenafil versus placebo use in the treatment of early-to-insomnia women in postmenopausal phase on a single-dose regimen (10 grams of sildenafil daily in a single dose), which resulted in significantly higher increases of plasma sildenafil concentration than that of the placebo group. While absolute difference was small, this outcome in contrast to those obtained male volunteers using 100 or 500 mg of sildenafil daily. In a retrospective analysis of these two studies, the groups showed significantly difference in systolic and diastolic blood pressure from premenopausal to postmenopausal by a large number of data points in males [14,15]. Both of our studies have demonstrated that the use of sildenafil in treatment the early-to-insomnia women postmenopausal phase leads to a significantly higher increase in plasma sildenafil concentration. addition, these studies have described a similar trend with regard to the development of hypertension [4,4,16]. Other results from long-term postmenopausal female subjects with severe hypertension reveal similarly strong results as shown from the study using subcutaneous patches for sildenafil [17]. The main Where can i buy tobradex ointment reason for such strong results is that the drug, similar to other antihypertensive drugs, acts as a diuretic [18]. These findings indicate that the administration of therapeutic doses sildenafil, in the treatment of early-to-insomnia women in early phase, has a positive beneficial effect on both diastolic and systolic blood pressure, which decreases cardiac mortality [36-38]. Although systolic blood pressure did not increase significantly with sildenafil alone against the placebo group, it is worth noting that the sildenafil group had an average diastolic blood pressure greater than the other groups. Interestingly, several authors have observed significant changes between groups in systolic blood pressure but have not described increased systolic blood pressure significantly different in the two groups [4-12,13-19], which could potentially explain our results. While the blood pressure response may depend on the dose of sildenafil, it seems logical to assume that given the potential to improve blood clotting Sildenafil 100mg $93.12 - $1.03 Per pill and thrombogenesis, a more important part of the blood pressure response on sildenafil in the early-to-insomnia women is from a lower concentration of sildenafil in blood than that achieved on placebo due to the improved regulation of diastolic blood pressure. It has been suggested that drug-induced hypotensive effects may result in an enhancement of diastolic blood pressure response in patients [20], but these results could not be reproduced in this study by the administration of sildenafil alone to postmenopausal women with hypertension. The lack of difference between groups could be explained by the fact that postmenopausal women receiving sildenafil were able to maintain a higher level of plasma sildenafil even when blood pressure was tested during post-sildenafil discontinuation [14,15]. The lac